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For instance, Fer-1, similar to other hydrophobic drug candidates, is unsuitable for clinical development because of its limited capacity to traverse the blood-brain barrier (BBB) and its poor water solubility [216]

Possible side effects, especially when consumed in large amounts or by supplementation, are summarized below: - Gastrointestinal discomfort: Some people report digestive symptoms such as diarrhea, gas or stomach upset after consuming sulforaphane supplements or large amounts of broccoli and other cruciferous vegetables

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